This paper introduces the OPIAID algorithm, a novel approach for predicting and recommending personalized opioid dosages for individual patients. The algorithm optimizes pain management while minimizing opioid related adverse events (ORADE) by employing machine learning models trained on observational electronic health records (EHR) data. It leverages a causal machine learning approach to understand the relationship between opioid dose, case specific patient and intraoperative characteristics, and pain versus ORADE outcomes. The OPIAID algorithm considers patient-specific characteristics and the influence of different opiates, enabling personalized dose recommendations. This paper outlines the algorithm's methodology and architecture, and discusses key assumptions, and approaches to evaluating its performance.

BERT-based models for Electronic Health Records (EHR) have surged in popularity following the release of BEHRT and Med-BERT. Subsequent models have largely built on these foundations despite the fundamental design choices of these pioneering models remaining underexplored. To address this issue, we introduce CORE-BEHRT, a Carefully Optimized and Rigorously Evaluated BEHRT. Through incremental optimization, we isolate the sources of improvement for key design choices, giving us insights into the effect of data representation and individual technical components on performance. Evaluating this across a set of generic tasks (death, pain treatment, and general infection), we showed that improving data representation can increase the average downstream performance from 0.785 to 0.797 AUROC, primarily when including medication and timestamps. Improving the architecture and training protocol on top of this increased average downstream performance to 0.801 AUROC. We then demonstrated the consistency of our optimization through a rigorous evaluation across 25 diverse clinical prediction tasks. We observed significant performance increases in 17 out of 25 tasks and improvements in 24 tasks, highlighting the generalizability of our findings. Our findings provide a strong foundation for future work and aim to increase the trustworthiness of BERT-based EHR models.

Experts at the University of Copenhagen, Denmark, have begun using artificial intelligence to create computer models that calculate the risk of a corona patient's needing intensive care or a ventilator. As coronavirus patients are hospitalized, it is difficult for doctors to predict which of them will require intensive care and a respirator. Many different factors come into play, some yet to be fully understood by doctors . As such, computer scientists at the University of Copenhagen are now developing computer models based on artificial intelligence that calculate the risk of an individual patient's need for a ventilator or intensive care. The new initiative is being conducted in a collaboration with Rigshospitalet and Bispebjerg Hospital.

Background. Real-world data show that approximately 50% of psoriasis patients treated with a biologic agent will discontinue the drug because of loss of efficacy. History of previous therapy with another biologic, female sex and obesity were identified as predictors of drug discontinuations, but their individual predictive value is low. Objectives. To determine whether machine learning algorithms can produce models that can accurately predict outcomes of biologic therapy in psoriasis on individual patient level. Results. All tested machine learning algorithms could accurately predict the risk of drug discontinuation and its cause (e.g. lack of efficacy vs adverse event). The learned generalized linear model achieved diagnostic accuracy of 82%, requiring under 2 seconds per patient using the psoriasis patients dataset. Input optimization analysis established a profile of a patient who has best chances of long-term treatment success: biologic-naive patient under 49 years, early-onset plaque psoriasis without psoriatic arthritis, weight < 100 kg, and moderate-to-severe psoriasis activity (DLQI $\geq$ 16; PASI $\geq$ 10). Moreover, a different generalized linear model is used to predict the length of treatment for each patient with mean absolute error (MAE) of 4.5 months. However Pearson Correlation Coefficient indicates 0.935 linear dependencies between the actual treatment lengths and predicted ones. Conclusions. Machine learning algorithms predict the risk of drug discontinuation and treatment duration with accuracy exceeding 80%, based on a small set of predictive variables. This approach can be used as a decision-making tool, communicating expected outcomes to the patient, and development of evidence-based guidelines.